topoisomerase inhibitor 2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T78717	Topoisomerase inhibitor 2		Topoisomerase
	Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].		Topoisomerase
T60617	Topoisomerase I inhibitor 2
	Topoisomerase I inhibitor 2 (ZML-8) is a highly selective DNA topoisomerase I (Top1) inhibitor that inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis with ...
T72154	Topoisomerase IV inhibitor 2		Topoisomerase
	Topoisomerase IV inhibitor 2 (compound 5d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.35 μM for TOPO IV and 0.55 μM for DNA gyrase. It also demonstrates antibacterial properties,...		Topoisomerase
T61045	Topoisomerase I/II inhibitor 2
	Topoisomerase I/II inhibitor 2 (compound 1a) can significantly reduce the xenograft tumor growth in mice model which can be used in treating liver cancer. Topoisomerase I/II inhibitor 2 is a DNA topoisomerase I/II dual i...
T3S1957	9-amino-CPT	Aminocamptothecin,9-amino-2(S)-camptothecin,9-Aminocamptothecin	Topoisomerase
	9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.		Topoisomerase
T5S0761	Nitidine chloride		Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite
	1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id...
T22456	Voreloxin hydrochloride	SNS-595 hydrochloride,Vosaroxin	Apoptosis , Topoisomerase
	Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.		Apoptosis , Topoisomerase
T7309	TAS-103 dihydrochloride	TAS-103 (dihydrochloride),BMS-247615 dihydrochloride	Topoisomerase
	TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.		Topoisomerase
T7048	1,4-Naphthoquinone	α-Naphthoquinone,Naphthalene-1,4-Dione,P-Naphthoquinone,para-naphthoquinone	Others , MAO , Topoisomerase
	1,4-Naphthoquinone (P-Naphthoquinone) was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase activity[1].		Others , MAO , Topoisomerase
T16697	Pyronaridine tetraphosphate		Topoisomerase
	Pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of DNA topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour activity.Pyronaridine tetraphosphate treats P. falciparum an...		Topoisomerase
T36968	ARN-21934		Topoisomerase
	ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etopo...		Topoisomerase
T64047	Topoisomerase II inhibitor 10
	Topoisomerase II inhibitor 10 is a potent inhibitor of topoisomerase II (IC50: 7.45 μM). Topoisomerase II inhibitor 10 was able to arrest the cell cycle of HepG-2 cells in the G2-M phase and induce apoptosis.
T61054	Type II topoisomerase inhibitor 1
	Type II topoisomerase inhibitor 1 is able to be used in the antibacterial area. Type II topoisomerase inhibitor 1 is a potent and selective inhibitor of E. coli DNA gyrase with a IC50 value of 1.7 nM as well as forms hyd...
T10832	CL2-SN-38		Others
	CL2-SN-38, a part of the antibody-drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. SN-38 is an inhibitor of DNA topoisomerase I.		Others
T62224	Topoisomerase IIα-IN-2
	Topoisomerase IIα-IN-2 (compound 5) is a DNA-binding ligands and a potent inhibitor of the topoisomerase TopoIIα. Topoisomerase IIα-IN-2 exhibits high anti-proliferative activity in human cancer cell lines. Topoisomerase...
T6724	Voreloxin	Vosaroxin,AG 7352,SNS-595	Apoptosis , Topoisomerase
	Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.		Apoptosis , Topoisomerase
T70201	S 16020-2
	S 16020-2 is an olivacine derivative, and DNA topoisomerase II inhibitor endowed with a remarkable antitumor activity against various experimental tumors.
T62223	Topoisomerase IIα-IN-1
	Topoisomerase IIα-IN-1 (compound 2) is a DNA-binding ligands and a potent inhibitor of TopoIIα, a topoisomerase. topoisomerase IIα-IN-1 shows good anti-proliferative effects on human cancer cell lines.
T36301	PluriSIn #2
	PluriSIn #2 acts as a selective transcriptional inhibitor of topoisomerase II α (TOP2A) and effectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1].
T78630	Exatecan mesylate dihydrate	DX-8951 mesylate dihydrate	Topoisomerase
	Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].		Topoisomerase